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Larsson, S.C. et al. Magnesium Intake and Risk of Type 2

statin

drugs

may

require

higher

doses.

Studies

Diabetes:

a

Meta-analysis.

Journal

of

Internal

Medicine, 2007, Vol. 262, pp. 208-14.

Editor’s comments: One multivitamin pill typically contains 100 to 200 mg of magnesium. Magnesium is readily available as an individual supplement, either alone or combined with calcium. Intakes of considerable more than 100 mg per day are recommended by some experts. The reader is referred to the book by Seelig and Rosanoff, The Magnesium Factor, Avery (Penguin, 2003), for an excellent and comprehensive account of the health benefits of adequate magnesium intake.

COENZYME Q-10 AND PRESSURE Coenzyme Q-10 (CoQ-10) i

HIGH BLOOD

s an integral and

essential

component

of

the

mitochondrial

respiratory chain for energy production and is found in all tissues and organs of the body with the highest concentrations in the heart. Blood levels decrease with aging and cardiovascular disease and are reduced by many statin cholesterol lowering drugs. A CoQ-10 deficiency has been implicated in heart failure and hypertension. A recent analysis of existing trials of CoQ-10 for treating hypertension has just reported. The study examined 12 clinical trials with 362 participants and involved randomized placebo controlled trials, crossover trials and open-

label trials. A blood pressure effect was found

crossover

trials showed

similar

results

decreases

in systolic blood

pressure

ranging

trials.

The

prospective

randomized

trials

in all and with from

11 mm Hg randomized

in the crossover to 17 studies. A decrease in

mm Hg in the diastolic blood

pressure was observed in these designs. Open label changes ranging from 10 diastolic changes from 7 to varied from 34 mg/day to

studies with either of studies found systolic to 21 mm Hg, and 16 mm Hg. Dosages

2256

mg/day.

In

the

reported very few minor side effects, or none at all. Rosenfeldt, F.L. et al. Coenzyme Q-10 in the Treatment of Hypertension: a Meta-analysis of Clinical Trials.

Journal of Human Hypertension, 2007, Vol. 297.

21, pp.

Editor s

comments:

The

changes

in

blood

pressure described above are large enough to move one from borderline hypertension to the normal range. Recent attempts to increase the bioavailability of CoQ-10 have resulted in some modern preparations with much higher bioavailability than older preparations such as were used in all of the trials analyzed in the above study. H o w e v e r , c a r e m u s t b e t a k e n i n p u r c h a s i n g t h i s enzyme to make sure that there enhanced bioavailability. is genuine

VITAMIN B6 AND COLORECTAL CANCER A recently reported study from Japan found that the intake of vitamin B6 was inversely related to the risk of colorectal cancer. Dietary intake was determined by a questionnaire. Mean intakes were 1.09 mg/day for the lowest quartile and 1.91 mg/day for the

highest. When were compared, 69% was found.

the lowest and highest quartiles an approximate risk reduction of Men who had an alcohol intake of

150 g/week (about 10 drinks) had more the risk of colorectal cancer than those less if they were in the lowest quartile of

than twice who drank intake, but

the risk those in

associated the highest

with alcohol quartile. The

disappeared for authors conclude

that while associated

higher intake of with reduced risk of

dietary B6 was colorectal cancer,

the

effect

was

primarily

seen

in

men

who

consumed

alcohol. Vitamin B6 potatoes, beer and

was derived from sake (Japanese

rice, tuna fish, rice wine). All

subjects were Japanese. Ishihara, J. et al. Low Intake of Vitamin B-6 is Associated with Increased Risk of Colorectal cancer in Japanese Men. Journal of Nutrition, 2007, Vol. 137, pp. 1810-14.

largest study, it was changes came about and required varying

found that the blood pressure gradually over several months doses in different patients (72-

360 mg/day) to

achieve

what

was considered

a

therapeutic dose

yielding

blood

levels of CoQ-10

of

  • >

    2.6 µg/ml.

The authors comment that patients on

Editor’s comments: These results are particularly interesting since the amounts of vitamin B6 are low compared to what is found in typical multivitamin

preparations.

For

example,

the

Centrum

multivitamins contain 3-8 mg, and Life Extension’s “Two-per-day” brand contains 75 mg per recommended daily dose.

International Health News

November 2007

Page 8

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