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The purpose of investigation was evaluation of the general protein level and its fractions during different seasons.

Materials and methods of the investigation. 341 donors of plasma for fractionation, i.e. 199 males and 142 females aged 18 through 65 years were examined. Laboratory studies were carried out in accordance with the Russian ministry of Public Health Order № 364 “On ratification of procedure for medical examination of donors of blood and its components” in the wording of the Russian ministry of Public Health and Social Development Order from 16.04.2008, the number 175n. The studies included determination of the general protein levels and its fractions: albumin, aggregate globulins, 1- globulins, 1- globulins, 2- globulins and – globulin. Statistical processing of the results was performed using regressive and single-factor dispersion analysis.

Results of the investigation and discussion. Statistical analysis of indicates for the four seasons (winter, spring, summer, autumn) was made in separate male and female groups. The registered levels of albumin, aggregate globulins, 1- globulins, 1- globulins, 2- globulins and – globulins were in all donors within the range of normal indices. A comparative avaluation of the seasonal factor effect on the protein composition of the plasma in males and females revealed certain regularities.

The following table shows the results obtained in the investigation of the protein metabolism in the donors of plasma for fractionation depending on the season.

Table

Indices for protein metabolism in the donors of plasma for fractionation

Season

Males

Females

n

M

m

s

V

n

M

m

s

V

General proteins

Winter

22

65,93

1,26

6,91

10,5%

21

69,1

1,89

8,66

12,5%

Spring

45

66,98

0,87

5,85

8,7%

40

67,65

1,19

7,53

11,1%

Summer

60

67,45

0,81

6,25

9,3%

31

69,42

1,14

6,37

9,2%

Autumn

72

68,97

0,82

6,99

10,1%

56

69,45

0,99

7,44

10,7%

Albumin

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