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© Sh.I. Ibragimov, T.U. Abdullaev, 2010

Ibragimov Sh.I., Abdullaev T.U. HLA-antigen association with climacteric keratoderma // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.

Scientific Research Institute of Dermatology and Venerology of Health Ministry of the Republic of Uzbekistan. Tashkent, Uzbekistan, Faroby str., 3, tel.: 8(371) 150-71-05, fax: 8(371) 214-50-68. E-mail: www. niidiv.uz

Summary: Last years great interest is marked to problem of keratoderma, particularly to climacteric keratoderma (CK) as one more often occuring in women of climacteric period. The aim of our study was research of antigens HLA his to compatibility in patients with climacteric keratoderma. The results of taken researches have shown, that be genotyping of alleles HLA-В17 in women with CK, revealed markers of predisposition and resistance to CK.

Key words: climacteric keratoderma; HLA; genotype.

References

1. Каламкарян А.А. Синдром Хакстхаузена климактерическая ладонно-подошвенная кератодермия / А.А. Каламкарян, Е.Г.Федорова, Е.В. Бухарина // Вестн. Дерматол. и венерологии. - 1984. - № 9. - С. 4-6.

2. Рахимова Д.А. Распределение HLA-антигенов в узбекской популяции Ташкентской области / Д.А. Рахимова, А.Т. Исхаков, Р.М. Рузыбакиев // Актуальные вопросы иммунологии и аллергологии. – Ташкент, 1996. - Т.8. - С.149-155.

3. Хаитов Р.М. Иммуногенетика и иммунология: резистентность к инфекциям / Р.М. Хаитов, В.М. Манько, Л.П. Алексеев. – Ташкент: Ибн-Сино, 1991. - 454 с.

4. Luca Gavalli-Sforza L. The history and geography of human genes / L. Luca Gavalli-Sforza, P. Menozzi, A. Piazza. - USA. - 1996. – 356 р.

Information about the authors:

Ibragimov Sharof Ismailovitch - doctor of medicine, head of the Scientific Research Institute of Dermatology and Venerology of Health Ministry of the Republic of Uzbekistan. Оffice phone: 8(371) 150-71-05, mob.ph: (+99890) 370-95-

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