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©A.G. Kozyrev, E.A. Surkova, A.Yu. Gichkin, V.E. Perley, 2010

Kozyrev A.G., Surkova E.A., Gichkin A.Yu., Perley V.E. Endotelin-1 content in patients with bronchial asthma with concomitant hypertensive disease // Preventive and clinical medicine. – 2010. - № 2 (35). – Р.

State Educational Establishment for Higher Professional Training «Saint-Petersburg State I.P. Pavlov Medical University of the Federal Agency for Public Health and Social Development of the Russian Federation». Russia, 197022, St.-Petersburg, Lev Tolstoy str. 6/8. Tel. 8(812)4997153, fax 8(812)2340897.

Summary: Serum levels of endothelin-1 were investigated in 80 asthmatic subjects. Serum level of endothelin-1 after the treatment of asthma exacerbation was higher in patients with concomitant essential hypertension, stage I, than in patients with optimal and normal blood pressure.

Key words: bronchial asthma, essential hypertension, endothelin-1

Endothelin 1 (ET-1) represents a polypeptide that has many biological effects, and can act as an autocrine/paracrine mediator. Apart from having vasoconstrictive function ET-1 can also be characterized with pro-inflammatory and proliferative activity, can stimulate production of free radicals, and may activate platelets. ET-1 is considered as one of the major components that results in endothelial dysfunction and cardiovascular disorders [1]. It is known [9] that ET-1 has a profound effect in pathogenesis of lung diseases, including bronchial asthma (BA). Lungs represent tissue site where ET-1 undergoes metabolic turnover.

Aim of study – to evaluate serum concentration of ET-1 in patients with bronchial asthma and concomitant essential hypertension (EH).

Materials and Methods. In our study we included 80 BA patients who visited a pulmonologist due to exacerbation of disease. This group of patients was composed of 21 male and 59 females, average age 54.0 ± 1.0 years old. In 5 patients mild persistent BA (mBA) was diagnosed, in 56 – moderate BA (moBA), in 19 – severe BA (sBA). 33 BA patients (Group I) had optimal or normal values of blood pressure (BP). In 10 patients (Group II) high normal BP was

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