mg a day) and/or amlodipine (5 mg a day) or by using them as combination drug – 10 mg lisinopril plus 5 mg amlodipine, daily (35 patients, including 17 patients with BA and concomitant EH stage I, and 18 patients with BA and concomitant EH stage II).
Statistical analysis was performed according to the general routine methods by using software STATISTICA 6.0. All data are shown as mean value (М) ± SE (m). Statistical significance between groups was calculated with a Student’s t-test. To measure relationship between studied parameters we calculated correlation coefficient (r).
Results and Discussion. In Table 1 we show a distribution of examined patients according to BA severity as well as the presence of concomitant EH. There was found that BA severity was associated with higher probability of concomitant EH.
Distribution of examined patients according to
BA severity level and concomitant EH
Groups of patients
3 (66.6 %)
2 (33.3 %)
5 (100 %)
26 (46.4 %)
6 (10.0 %)
12 (21.4 %)
12 (21.4 %)
56 (100 %)
4 (21.1 %)
2 (10.6 %)
7 (36.8 %)
6 (31.6 %)
19 (100 %)
During the treatment a positive dynamics of both airway flow index as well as BP values was documented. In particular, we saw that during the second examination prior to blood sampling patients with EH had systolic BP that decreased by 6.2±1.8 mmHg (4.7±2.8 mmHg in Group III and 7.5±2.5 mmHg in Group IV), whereas diastolic BP decreased by 4.7±1.7 mmHg (3.1±2.8 mmHg in Group III and 6.1±2.1 mmHg in Group IV).
All examined patients did not show signs of severely increased pulmonary artery systolic pressure (PASP) that was equal to 30.0±0.4 mmHg. No significant differences were found in PASP values among groups with patients having mild,