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SAINT-PETERSBURG – 2010 - page 58 / 128

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Groups of patients

Before treatment

After treatment

I, n=33

0.224±0.038

0.207±0.027*

II, n=10

0.225±0.054

0.257±0.043

III, n=19

0.196±0.022§

0.315±0.053*§

IV, n=18

0.290±0.060

0.224±0.043

Control group, n=10

0.208±0.025

Comments. * – statistically significant differences between groups, p<0.05.

§ – statistically significant differences are found before and after treatment, p<0.05.

Previously there was shown that ET-1 levels may be increased in patients with BA. In some cases ET-1 levels were tend to normalize while airway narrowing is getting improved [3]. In our study we found that serum ET-1 level in BA patients was comparable with that one from subjects of control group. At the same time, during the first examination moderate significant correlation between ET-1 level and relative increase of forced expiratory volume in 1 second (as compared with basic value) was shown. For the whole group correlation coefficient was 0.29, р=0.011. Magnitude of correlation was going up in parallel with BA severity level. In particular, correlation was insignificant in patients with mild BA, whereas in case of moderate BA correlation coefficient was reaching 0.32, р=0.019, and in patients with severe BA it was reaching up to 0.46, р=0.049.

During the last 20 years a role of ET-1 in development and progression of arterial hypertension has been widely debated. It is known that despite its vasopressor capacity ET-1 was increased only in few patients with arterial hypertension [2], including patients with pheochromocytoma [8], patients with arterial hypertension associated with obesity [6]. Course of arterial hypertension may be ameliorated by using angiotensin converting enzyme inhibitors, that can be accompanied with decrease of ET-1 levels [4]. In our study we have found that ET-1 concentration after treatment in BA patients with concomitant EH stage I was higher than in subjects who had optimal or normal BP values.

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