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than in  patients with optimal and normal blood pressure.

Key words: bronchial asthma; essential hypertension; endothelin-1.

References

1. Böhm F. The importance of endothelin-1 for vascular dysfunction in cardiovascular disease / F. Böhm, J. Pernow // Cardiovasc Res. – 2007. – Vol. 76. - № 1. - P. 8-18.

2. Dhaun N. Role of endothelin-1 in clinical hypertension: 20 years on / N. Dhaun, J. Goddard, D.E. Kohan // Hypertension. – 2008. – Vol. 52. - № 3. - P. 452-459.

3. Fagan K.A. Role of endothelin-1 in lung disease / K.A. Fagan, I.F. McMurtry, D.M. Rodman // Respir. Res. – 2001. - Vol. 2. - № 2. – Р. 90–101.

4. Hlubocká Z. Is mild essential hypertension without obvious organ complications and risk factors associated with increased levels of circulating markers of endothelial dysfunction? Effect of ACE inhibitor therapy / Z. Hlubocká, V. Umnerová, S. Heller // Vnitr. Lek. – 2002. – Vol. 48. - № 8. – Р. 718-723.

5. Lal H. Hypoxia augments conversion of big-endothelin-1 and endothelin ET(B) receptor-mediated actions in rat lungs / H. Lal, Q. Yu, K.I. Williams, B. Woodward // Eur. J. Pharmacol. – 2000. – Vol. 402. - № 1-2. Р. 101-110.

6. Letizia C. High circulating levels of adrenomedullin and endothelin-1 in obesity associated with arterial hypertension / C. Letizia, M. Celi, S. Cerci // Ital. Heart J. Suppl. – 2001. - Vol. 2. - № 9. – Р. 1011-1015.

7. Naline E. Modulation of ET-1-induced contraction of human bronchi by airway epithelium-dependent nitric oxide release via ETA receptor activation / E. Naline, C. Bertrand, K. Biyah // Br. J. Pharmacol. - 1999 - Vol. 126. - № 2. – Р. 529–535.

8. Oishi S. Elevated immunoreactive endothelin levels in patients with phaeochromocytoma / S. Oishi, M. Sasaki, T. Sato // Am. J. Hypertens. – 1994. – Vol. 7. - № 8. – P. 717–722.

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