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For Information OnlyBreast

MXPresence of distant metastasis cannot be assessed

M0No distant metastasis

M1Distant metastasis

Stage Groupings

Stage 0TisN0M0

Stage I T1# N0 M0

Stage IIA T0 N1 M0

T1# N1 M0

T2 N0 M0

Stage IIB T2 N1 M0

T3N0 M0

Stage IIIA T0 N2 M0

T1# N2 M0

T2 N2 M0

T3 N1M0


Stage IIIBT4 N0,N1,N2 M0

Stage IIICAny T N3 M0

Stage IVAny T Any N M1

# T1 includes T1mic.

TNM Descriptors

For identification of special cases of TNM or pTNM classifications, the “m” suffix and “y,” “r,” and “a” prefixes are used. Although they do not affect the stage grouping, they indicate cases needing separate analysis.

The “m” suffix indicates the presence of multiple primary tumors in a single site and is recorded in parentheses: pT(m)NM.

The “y” prefix indicates those cases in which classification is performed during or following initial multimodality therapy (ie, neoadjuvant chemotherapy, radiation therapy, or both chemotherapy and radiation therapy). The cTNM or pTNM category is identified by a “y” prefix. The ycTNM or ypTNM categorizes the extent of tumor actually present at the time of that examination. The “y” categorization is not an estimate of tumor prior to multimodality therapy (ie, before initiation of neoadjuvant therapy).

The “r” prefix indicates a recurrent tumor when staged after a documented disease-free interval, and is identified by the “r” prefix: rTNM.

The “a” prefix designates the stage determined at autopsy: aTNM.

Additional Descriptors

Residual Tumor (R)

Tumor remaining in a patient after therapy with curative intent (eg, surgical resection for cure) is categorized by a system known as R classification, shown below.

RXPresence of residual tumor cannot be assessed

R0No residual tumor

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