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For Information OnlyBreast

The sentinel lymph node is the first node to receive drainage from a primary tumor. There may be more than 1 sentinel node for some tumors. If a sentinel node contains metastatic tumor, it indicates that other more distant nodes may also contain metastatic disease. If sentinel nodes are negative, other regional nodes are less likely to contain metastasis. Sentinel lymph nodes that have been examined for ITCs are denoted as follows:

pN0(sn)No sentinel lymph node metastasis histologically (ie, none greater than 0.2 mm), no additional examination for isolated tumor cells (ITCs)

pN0(i-)(sn)No sentinel lymph node metastasis histologically (ie, none greater than 0.2 mm), negative morphologic findings for ITCs

pN0(i+)(sn)No sentinel lymph node metastasis histologically, positive morphologic findings for ITCs

pN0(mol-)(sn)No sentinel lymph node metastasis histologically, negative nonmorphologic findings for ITCs

pN0(mol+)(sn)No sentinel lymph node metastasis histologically, positive nonmorphologic findings for ITCs


1.Winchester DP, Cox JD, et al. Standards for diagnosis and management of invasive breast carcinoma. CA Cancer J Clin. 1998;48:83-107.

2. Rosen PP, Oberman HA. Tumors of the mammary gland. In: Atlas of Tumor Pathology. 3rd Series. Fascicle 7. Washington, DC: Armed Forces Institute of Pathology, American Registry of Pathology; 1993.

3. Histological typing of breast tumours. In: International Classification of Tumours. 2nd ed. Geneva, Switzerland: World Health Organization; 1981.

4.Bloom HJG, Richardson WW. Histological grading and prognosis in breast carcinoma: a study of 1049 cases of which 359 have been followed for 15 years. Br J Cancer. 1957;11:359-377.

5.Elston CW, Ellis JO. Pathological prognostic factors in breast cancer: experience from a long study with long-term follow-up. Histopathology. 1991;19:403-410.

6.Fitzgibbons PL, Page DL, Weaver D, et al. Prognostic factors in breast cancer: College of American Pathologists consensus statement, 1999. Arch Pathol Lab Med. 2000;124:966-978.

7. Henson DE, Ries L, Freedman LS, Carriaga M. Relationship among outcome, stage of disease, and histologic grade for 22,616 cases of breast cancer. Cancer. 1991;68:2142-2149.

8. Schwartz GF, Lagios MD, Carter D, et al. Consensus conference on the classification of ductal carcinoma in situ. Cancer. 1997;80:1798-1802.

9. Holland R, Hendriks JHCL, Verbeek ALM, et al. Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet. 1990;335:519-522.

10.Winchester DP, Strom EA, et al. Standards for diagnosis and management of ductal carcinoma in situ (DCIS) of the breast. CA Cancer J Clin. 1998;48:108-128.

11. Connolly JL, Boyages J, Nixon AJ, et al. Predictors of breast recurrence after conservative surgery and radiation therapy for invasive breast cancer. Mod Pathol. 1998;11:134-139.

12. Gage I, Schnitt SJ, Nixon AJ, et al. Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer. 1996;78:1921-1928.

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