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BreastCAP Approved

Histologic Grade (any grading system may be used; mitotic count is also required independent of the grading system)

Nottingham Histologic Score (If not used, see Other Grading System below)

Tubule Formation

___ Majority of tumor greater than 75% (score = 1)

___ Moderate 10% to 75% (score = 2)

___ Minimal less than 10% (score = 3)

Nuclear Pleomorphism

___ Small regular nuclei (score = 1)

___ Moderate increase in size, etc (score = 2)

___ Marked variation in size, nucleoli, chromatin clumping, etc (score = 3)

Mitotic Count (for those using Nottingham system)

For a 25x objective with a field area of 0.274 mm2

___ Less than 10 mitoses per 10 HPF (score = 1)

___ 10 to 20 mitoses per 10 HPF (score = 2)

___ Greater than 20 mitoses per 10 HPF (score = 3)

or

For a 40x objective with a field area of 0.152 mm2

___ 0 to 5 mitoses per 10 HPF (score = 1)

___ 6 to 10 mitoses per 10 HPF (score = 2)

___ Greater than 10 mitoses per 10 HPF (score = 3)

Total Nottingham Score

___ Grade I: 3-5 points

___ Grade II: 6-7 points

___ Grade III: 8-9 points

___ Score cannot be determined

Other Grading System

Specify grading system: ____________________________

___ Grade 1

___ Grade 2

___ Grade 3

___ Grade cannot be determined

Mitotic Count (for those using other grading systems)

___ Number of mitoses per 10 HPF

Pathologic Staging (pTNM)

Primary Tumor (pT)

___ pTX:Cannot be assessed

___ pT0:No evidence of primary tumor

*  Data elements with asterisks are not required for accreditation purposes for the Commission on Cancer. These elements may be clinically important, but are not yet validated or regularly used in patient management. Alternatively, the necessary data may not be available to the pathologist at the time of pathologic assessment of this specimen.

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