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SME Specific MeasuresQuality of Life and Management of Living Resources

Exploratory Award

Proposal number EXAW-1999-00951

AcronymADENGIOGENETHERAPY

Proposal titleADENOVIRAL MEDIATED PRO/ANTI ANGIOGENESIS GENE THERAPY FOR

OSTEOPOROSIS AND METASTATIC BONE DISEASE

AbstractThe socio-economic problem to overcome is that for both diseases: osteoporosis and

metastatic bone disease there is no satisfactorily treatment. The quality of life of these

patients and their environment is greatly affected and their life expectancy is limited. This

is particularly true for patients being diagnosed with bone metastasis where the average life

expectancy shortens to 18 to 24 months. Both osteogenesis and bone metastasis are

stimulated by angiogenesis which can be seen as a common denominator. In the case of

osteoporosis one would like to enhance angiogenesis whereas in the case of tumor growth

one wants to suppress angiogenesis. The specific research objectives are aimed at

UTILIZING GENE TARGETTING AND GENE THERAPY NOVEL TECHNOLOGIES

IN ORDER TO: I.   INHIBIT ANGIOGENESIS IN METASTATIC BONE DISEASE II.  

ENHANCE BONE FORMATION IN BONE LESIONS AND OSTEOPOROSIS

Key ActionQOL-GEN.  Generic activities

Start date6/07/2000End date6/07/2001

Intended Step 2 projectRTD Project (Collaborative Research)Duration Exploratory Phase12 months

SME CoordinatorProf. Dr. Domenico VALERIOCompany sizeS4

INTROGENE BV

Wassenaarseweg 72

PO Box 2048

2301 CA - Leiden

The Netherlands

Phone: 31715248701

Fax: 31715248702

Email: info@introgene.com

Internet: http://www.introgene.com

SME Proposer(s)

Non-SME End User(s)

HADASSAH MEDICAL ORGANISATION (GENE IsraelS4

THERAPY INSTITUTE)

Profile of partners for joining the project

Business areas73-L - Research and experimental development on natural sciences and engineering

CommentsGene  Therapy CentreImmunosystem specialist

Last update18/6/2001

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