cont. from page 18
to numbers of related addisonians,
To send a Standard Poodle sample to the lark lab,
breeders should consider each affected onset, severity of onset and any extreme tal exposure to determine different levels assessing depth and breadth of pedigree.
dog’s age of environmen- of risk when
in order for breeders to make the safest breeding choices possible, all addison’s disease must be publicly reported. for Standard Poodles, the best and most reliable method of tracking most health issues is the Poodle health registry, www.poodlehealthre- gregistry,
you can contact me at email@example.com_
com) . any samples sent to the lark lab will also be sent to uC davis after they are compared to PWd samples. To send samples directly to uC davis, and for more information, go to:
health issues and test results, good and bad, are also included in the Phr’s online database at www.phrda- tabase.online database at www.phrdatabase.<Wbr>org . pedigrees of their own dogs and prospective mates in order to make the most informed decisions possible. Pet owners can review pedigrees when deciding to adopt puppies.
blood and serum samples from Standard Poodles are requested by both uC davis and the lark lab. These are necessary for new technology, which offers a more efficient and accurate way to analyze DNA than ever before. Samples from any addison’s affected dogs are requested, as well as from dogs that are most likely unaffected, which means healthy, older dogs. any healthy dog 8 years old and over is a good candidate, preferably those with no parent, offspring or sibling with addison’s. This requires a visit to the vet, but the process is very simple and brief for those who worry about their dogs’ reaction to stress. many vet- erinarians will do this for free when it is for research purposes.
additionally, adrenal gland tissue samples from both affected and older healthy Standard Poodles are also needed by uC davis. They will use these to com- pare the DNA findings with the actual expression of genes so they can better understand how the disease progresses and how the different loci may interact to yield the disease. if in the near future your poodle is euthanized and you would like his or her tissue to help this crucial cause, you can discuss this with your veterinarian prior to such an occurrence. The vet can then put a note in your dog’s file with instructions so that it won’t be necessary to discuss at a more emo- tional time.
A recent, significant study on Addison’s Disease has
data that supports a complexly inherited trait, not an autosomal recessive mode of inheritance.
dna and tissue samples from addisonians and old-
er healthy dogs are urgently needed to complete this research. go to _http://cgap.http://cgap.http://cghttp://cgahtt_ (http://cgap.ucdavis.edu/ST%20kit%20request.htm) for more information,or email firstname.lastname@example.org_ (mailto:email@example.com) .
breeders should proceed with the assumption that
addison’s is a polygenic disease.
breed high risk dogs to highly unrelated dogs with
do not remove producers or offspring of addisoni-
ans from the gene pool; instead, replace them with high quality offspring or parent with lower risk.
assess both the status of direct ancestors as well as
all lateral relatives when considering a breeding.
note ages of onset, severity of onset, and environ-
mental conditions and events for every individual ad- disonian.
Publicly report all cases of addison’s disease, pref-
erably to the Poodle health registry at www.poodlehealthregPoo- dle hea
much thanks goes to the Poodle community in antici- pation of your generous support!
natalie green Tessier Poodles de grenier