CTC NOTICE OF MODIFICATIONS
Version 2.0 Publish Date: April 30, 1999
Adverse Event Proctitis
Also consider Hemorrhage... Notes: Fistula is graded... Proctitis occurring...
The Also consider for Proctitis was changed to Hemorrhage/bleeding with grade 3 or 4 thrombocytopenia, Hemorrhage/bleeding without grade 3 or 4 thrombocytopenia, Pain due to radiation (the word “and” was deleted).
Salivary gland changes
Sense of smell
Stomatitis/pharyngitis (oral/pharyngeal mucositis)
For BMT studies, if specified in the protocol.
The spelling for the word prophylactic was corrected.
Note: Radiation-related mucositis...
Taste disturbance (dysgeusia)
The Grade 3 criteria for Typhlitis was revised to abdominal pain, diarrhea, fever, and radiographic or biopsy documentation.
Typhlitis (inflammation of the cecum)
Also consider Hemorrhage/...
The term Febrile/neutropenia in the Also consider for Typhlitis was changed to Febrile neutropenia (“/” was deleted).
Also consider Dehydration. Weight gain is graded in… Weight loss is graded in...
Gastrointestinal – Other (Specify, __________)
Cancer Therapy Evaluation Program Common Toxicity Criteria, Version 2.0 DCTD, NCI, NIH, DHHS March 1998
Revised March 23, 1998