CTC NOTICE OF MODIFICATIONS
Version 2.0 Publish Date: April 30, 1999
Notes: Transfusion in this... For any bleeding with...
The Note beginning with “For any bleeding with…” was revised to …in addition to grading severity by grading the site or type of bleeding.
If the site or type of Hemorrhage...
If the platelet...
Hemorrhage/bleeding with grade 3 or 4 thrombocytopenia
Also consider Platelets...
The Also consider for Hemorrhage/bleeding with grade 3 or 4 thrombocytopenia was revised to Platelets, Hemoglobin, Transfusion-platelets, Transfusion- p R B C s s i t e o r t y p e o f b l e e d i n g . I f t h e s i t e i s n o t l i s t e d , g r a d e a s H e m o r r h a g e -
Other (Specify site, _______).
Note: This adverse event must...
Hemorrhage/bleeding without grade 3 or 4 thrombocytopenia
Also consider Platelets... Note: Bleeding in... CNS hemorrhage/bleeding
The Note for Hemorrhage/bleeding with grade 3 or 4 thrombocytopenia was revised by deleting the sentence “Also grade the site or type of hemorrhage/ bleeding. If the site is not listed, grade as Other in the HEMORRHAGE category”.
The Also consider for Hemorrhage/bleeding without grade 3 or 4 thrombocytopenia
w a s r e v i s e d b y a d d i n g H e m o r r h a g e - O t h e r ( S p e c i f y s i t e
Hematuria (in the absence of vaginal bleeding)
Hemorrhage/bleeding associated with surgery
Note: Expected blood loss... Melena/GI bleeding
Cancer Therapy Evaluation Program Common Toxicity Criteria, Version 2.0 DCTD, NCI, NIH, DHHS March 1998
Revised March 23, 1998