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CTC NOTICE OF MODIFICATIONS

Version 2.0 Publish Date: April 30, 1999

Grade

Adverse Event

0

1

2

3

4

Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)

(ANC < 1.0 x 109/L, fever

  • 38.5°C)

Also consider Neutrophils. Note: Hypothermia instead…

Infection (documented clinically or microbiologically) with grade 3 or 4 neutropenia

(ANC < 1.0 x 109/L) Also consider Neutrophils. Notes: Hypothermia instead...

In the absence of...

Infection with unknown ANC

Note: This adverse event criterion...

Infection without neutropenia

The Also consider for Febrile neutropenia was added.

The Also consider for Infection was added.

G6

The Note for Infection (documented clinically or microbiologically) beginning with “In the absence of…” was revised to In the absence of documented infection grade 3 or 4 neutropenia with fever is graded as Febrile neutropenia.

G1

Also consider Neutrophils. Wound-infectious is...

The Also consider for Infection without neutropenia was added.

Infection/Febrile Neutropenia - Other (Specify, __________)

The Infection/Febrile Neutropenia - Other (Specify,

) event was moved to

appear as the last listing in the INFECTION/FEBRILE NEUTROPENIA Category.

LYMPHATICS

Lymphatics

Lymphatics - Other (Specify, __________)

METABOLIC/LABORATORY

Acidosis (metabolic or respiratory)

Alkalosis (metabolic or respiratory)

Amylase Bicarbonate

Cancer Therapy Evaluation Program Common Toxicity Criteria, Version 2.0 DCTD, NCI, NIH, DHHS March 1998

16

Revised March 23, 1998

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