CTC NOTICE OF MODIFICATIONS
Version 2.0 Publish Date: April 30, 1999
Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)
(ANC < 1.0 x 109/L, fever
Also consider Neutrophils. Note: Hypothermia instead…
Infection (documented clinically or microbiologically) with grade 3 or 4 neutropenia
(ANC < 1.0 x 109/L) Also consider Neutrophils. Notes: Hypothermia instead...
In the absence of...
Infection with unknown ANC
Note: This adverse event criterion...
Infection without neutropenia
The Also consider for Febrile neutropenia was added.
The Also consider for Infection was added.
The Note for Infection (documented clinically or microbiologically) beginning with “In the absence of…” was revised to In the absence of documented infection grade 3 or 4 neutropenia with fever is graded as Febrile neutropenia.
Also consider Neutrophils. Wound-infectious is...
The Also consider for Infection without neutropenia was added.
Infection/Febrile Neutropenia - Other (Specify, __________)
The Infection/Febrile Neutropenia - Other (Specify,
) event was moved to
appear as the last listing in the INFECTION/FEBRILE NEUTROPENIA Category.
Lymphatics - Other (Specify, __________)
Acidosis (metabolic or respiratory)
Alkalosis (metabolic or respiratory)
Cancer Therapy Evaluation Program Common Toxicity Criteria, Version 2.0 DCTD, NCI, NIH, DHHS March 1998
Revised March 23, 1998