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CTC NOTICE OF MODIFICATIONS

Version 2.0 Publish Date: April 30, 1999

Grade

Adverse Event

  • 0

    1

2

3

4

Muscle weakness (not due to neuropathy)

Myalgia [tenderness or pain...

The grading instructions for Myalgia was revised to Myalgia [tenderness or pain in muscles] is graded in the PAIN category.

Myositis (inflammation/damage of muscle)

Also consider CPK. Note: Myositis implies...

Osteonecrosis (avascular necrosis)

Musculoskeletal – Other (Specify, __________)

NEUROLOGY

Aphasia, receptive and/or...

Arachnoiditis/meningismus/ radiculitis

Also consider Headache... Ataxia (incoordination)

CNS cerebrovascular ischemia

CNS hemorrhage/bleeding is graded...

Cognitive disturbance/ learning problems

Cancer Therapy Evaluation Program Common Toxicity Criteria, Version 2.0 DCTD, NCI, NIH, DHHS March 1998

18

Revised March 23, 1998

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