CTC NOTICE OF MODIFICATIONS
Note: See the HEMORRHAGE...
DIC (disseminated intravascular coagulation)
Also consider Platelets. Note: Must have… Fibrinogen
The word grade was replaced with the word consider.
For leukemia studies or bone marrow infiltrative/ myelophthisic process, if specified in the protocol.
Partial thromboplastin time (PTT)
Phlebitis is graded... Prothrombin time (PT) Thrombosis/embolism is graded...
The spelling for the word Phlebitis was corrected.
Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura/TTP or hemolytic uremic syndrome/HUS)
For BMT studies, if specified in the protocol.
Also consider Hemoglobin... Note: Must have...
Coagulation - Other (Specify, __________)
Fatigue (lethargy, malaise, asthenia)
Note: See Appendix III...
Cancer Therapy Evaluation Program Common Toxicity Criteria, Version 2.0 DCTD, NCI, NIH, DHHS March 1998
Version 2.0 Publish Date: April 30, 1999
The Grade 4 value for Fibrinogen for leukemia studies or bone marrow infiltrative/ myelophthisic process was changed to <50mg (“%” was deleted).
Revised March 23, 1998