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Identifying skin neoplasms benign vs. malignancy - page 10 / 24

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Malignant Melanoma

Most serious form of skin cancer

6 most common cancer in the United States

Prognosis depends on depth of the primary tumor, anatomic location, and presence and extent of metastatic disease

Radial growth phase

Primarily confined to the epidermis and divides into two

Malignant melanoma in situ (MMIS) is proliferation restricted to the epidermis

Microinvasive extend to dermis

Vertical growth phase

Invasive, extending deeply into the dermis

Metastasizes first to the regional lymph nodes and then to secondary sites, most commonly skin, subcutaneous soft tissue and anywhere like lung or brain.

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