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Lab: Synthesis of Aspirin & Oil of Wintergreen - page 2 / 3

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Procedure:

A.

Synthesis of Acetylsalicylic Acid

1.

Day 1: Add about 200 mL of tap water to a 500 mL beaker and heat it to 80–90 C.  (Continue the procedure below while you are waiting.)

2.

Place about 2.0 g of salicylic acid in a 125 mL Erlenmeyer flask.  Record the exact mass.

3.

Once your water has reached the appropriate temperature range, take your salicylic acid flask to the hood and:

a.

Cautiously add 4.0 ml of acetic anhydride to your flask.

b.

Carefully add 4 drops of concentrated sulfuric acid to the flask and swirl to mix everything thoroughly.

c.

Place the flask in the beaker of warm water and heat the mixture for about 20 minutes.

4.

Remove the flask from the warm water and allow it to cool to room temperature.

5.

Cautiously add 30 mL of D.I. water to the mixture in the flask and thoroughly mix the contents by swirling.  Use the rubber policeman to transfer the mixture to a clean 50-mL beaker.

6.

Cool the mixture in an ice bath to complete the initial crystallization.

7.

Record the mass of a piece of filter paper, set it up, then transfer the products for filtering. Wash the crystals with 2-3 mL of chilled water.  Place the filter paper and product on a watch glass to dry overnight.

8.

Clean up all equipment; all chemicals can be rinsed down the drain.

9.

Day 2: Record the final mass of the filter paper and product, then put them in the trash.

B.

Synthesis of Methyl Salicylate

1.

Day 1: Place 1 g of salicylic acid and 5 mL of methyl alcohol in a large test tube.

2.

Add 3 drops of concentrated sulfuric acid and then place the test tube in a water bath at about 70C for about 15 minutes.  Note the odor.

Data and Observations: In the space below, create a data table to record the necessary quantitative information for this lab, as well as your observations of what occurred.  

9/10/2008

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