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Asthma Health Outcomes Project

Overviews of Surveyed Asthma ProgramsSeptember 2005

International Programs: The Netherlands (cont’d)Back to Index

Allergen-Avoidance Measure in Homes of House-dust-mite-allergic Asthmatic Patients: Effects of Acaricides and Mattress Encasings

University Hospital

9713 GZ Groningen The Netherlands

Sicco van der Heide, MS

s.van.der.heide@int.umcg.nl

This double-blind, placebo-controlled study investigated whether the application of an acaricide on mattresses and on textile floor coverings in living rooms and bedrooms could contribute to improvement in lung function and airway hyper responsiveness in 40 adult patients with asthma sensitized to house-dust mites. In a second group of 19 patients who refused chemical intervention, the clinical effects of application of allergen-impermeable mattress encasings were studied.

In all three treatment groups, Der p 1 levels in mattress dust were statistically significantly decreased after 12 months. Treatment of textile floors with either Acarosan or placebo chemical caused a statistically significant decrease in the level of the house-dust-mite allergen Der p 1 in floor dust. In the group with mattress encasings, no significant changes of floor dust Der p 1 were found. Airway hyper responsiveness improved significantly in the mattress cover group after 6 and 12 months. The Acarosan group also showed a small but statistically significant improvement after 12 months compared to baseline, but not between Active and Placebo treatment.

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