Causes of onset of labor (2)
The probable modes of action of oestrogen are:
--increase the release of oxytocin from maternal pituitary
--promotes the synthesis of receptors for oxytocin in the myometrium and decidua.
--accelerates lysosomal disintegration inside the decidual cells resulting in increased prostaglandin synthesis.
--stimulates the synthesis of myometrial contractile protein
---increase the excitability of the myometrial cell membranes.