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Report provided to the Human Fertilisation and Embryology Authority, April 2011 - page 15 / 45

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there is little or no transfer of abnormal mtDNA, this method could avoid mitochondrial disease not just in the resulting child, but also in subsequent generations.

Figure 1. Maternal spindle transfer technique

Figure 2. Pronuclear transfer technique11

11 Bredenoord, A and P. Braude (2010) “Ethics of mitochondrial gene replacement: from bench to bedside” BMJ 341. Image reproduced with permission of Author Page 15 of 45

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