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Report provided to the Human Fertilisation and Embryology Authority, April 2011 - page 2 / 45

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Executive summary 1. Introduction, scope and objectives 2. Background information on mitochondrial biology and disease 3. Review of preimplantation genetic diagnosis to avoid

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mitochondrial disease 4. Review of maternal spindle transfer and pronuclear transfer to

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avoid mitochondrial disease 5. Further research 6. Conclusions Annex A: Clinical disorders due to mutations in mtDNA Annex B: Methodology of review Annex C: Evidence reviewed Annex D: Glossary

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