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Report provided to the Human Fertilisation and Embryology Authority, April 2011 - page 24 / 45

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    • 6.8

      Although potentially useful clinical techniques, further safety experiments need to be done before introducing them into clinical practice.

    • 6.9

      Once assessed as safe to use in clinical practice, the panel strongly recommends that permission is sought from the parents of the children born from MST and PNT to be followed-up for an extensive period.

    • 6.10

      The following (minimum) set of experiments is critical. These experiments should be undertaken and the results taken into account before MST and PNT techniques can be assessed as safe to use clinically:

      • MST using human oocytes (eggs) that are then fertilised (not activated)

      • PNT using normally-fertilised human oocytes and development compared to normal ICSI-fertilised human oocytes

      • PNT in a non-human primate model, with the demonstration that the offspring derived are normal

Page 24 of 45

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