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Report provided to the Human Fertilisation and Embryology Authority, April 2011 - page 27 / 45





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Annex B: Methodology of review

  • 1.

    The Human Fertilisation and Embryology Authority (HFEA) agreed on 16 February 2011 to a request from the Secretary of State for Health to carry out a scientific review to scope “expert views on the effectiveness and safety of mitochondrial transfer”.

  • 2.

    In order to carry out this review, the HFEA established a small panel to collate and summarise the current state of expert understanding on the safety and efficacy of methods to avoid mitochondrial disease through assisted conception. Panel members were selected for their broad-ranging scientific and clinical expertise, and for having no direct interests in the outcome of the review.

  • 3.

    Membership of the panel:

    • -

      Professor Neva Haites (co-chair), University of Aberdeen

    • -

      Dr Robin Lovell-Badge (co-chair), Medical Research Council National Institute for Medical Research

    • -

      Professor Peter Braude, Kings College London

    • -

      Professor Keith Campbell, University of Nottingham

    • -

      Professor Sir Richard Gardner

    • -

      Professor Anneke Lucassen, Human Genetics Commission

  • 4.

    The panel put out a call for evidence on 28 February 2011. It asked for scientific evidence

on the safety and effectiveness of methods to avoid mitochondria disease through assisted conception from experts in any relevant field by 15 March 2011. The call for evidence was sent directly to more than 30 experts in the field and to 25 professional bodies. Recipients were invited to circulate the call to colleagues. The call for evidence was also published on the HFEA website23.

5. When submitting evidence, individuals were asked to indicate whether they were interested in discussing their evidence with the panel. Any researcher who expressed interest was



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