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Report provided to the Human Fertilisation and Embryology Authority, April 2011 - page 31 / 45





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  • Abstract Mitochondrial DNA replacement in a primate model Dr Shoukhrat Mitalipov, Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Stem Cell Center and Departments of Obstetrics & Gynecology and Molecular & Medical Genetics, Oregon Health & Science University

  • Abstract - Pre-implantation Genetic Diagnosis for the mitochondrial DNA m.8993T>G mutation yields a healthy child and evidence of selection for germ cells with high abnormal loads Professor David Thorburn, Head of Mitochondrial Research Group, Murdoch Childrens Research Institute, Victoria, Australia

  • Abstract - Successful application of preimplantation genetic diagnosis to reduce the transgenerational risk of transmitting a mitochondrial DNA disorder Dr Nathan Treff, Director of Molecular Biology Research, Reproductive Medicine Associates of New Jersey

  • 3.

    Published articles and reports

    • Report of 2010 MRC and Californian Institute of Regenerative Medicine joint workshop on SCNT: http://www.mrc.ac.uk/Utilities/Documentrecord/index.htm?d=MRC007577

  • Barrientos, A., L. Kenyon, et al. (1998). "Human xenomitochondrial cybrids. Cellular models of mitochondrial complex I deficiency." J Biol Chem 273(23): 14210-7

  • Barrientos, A., S. Muller, et al. (2000). "Cytochrome c oxidase assembly in primates is sensitive to small evolutionary variations in amino acid sequence." Mol Biol Evol 17(10): 1508-19

  • Baudouin, S. V., D. Saunders, et al. (2005). "Mitochondrial DNA and survival after

sepsis: a prospective study." Lancet 366(9503): 2118-21

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