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Dr Rick Last Specialist Veterinary Pathologist - page 21 / 24

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Feline hepatic lipidosis

Gross pathology: hepatomegaly with yellow-brown discolouration, rounded borders and increased friability.

Histopathology: microvesicular and macrovesicular vacuolar change which alters contour of hepatocytes and displaces the nucleus. Minimal inflammation.

Hematological abnormalities

  • -

    poikilocytosis (abnormally shaped erythrocytes) in

blood smears common due to abnormal erythrocyte lipid membrane metabolism.

  • -

    abnormal clotting profiles observed in up to 50% of

cats with HL. Prolongation of prothrombin time due to vitamin K deficiency most common.

  • -

    Hypofibrinogenemia is common.

Clinical chemistry abnormalities

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    hyperbilirubinaemia with > 2x increase in AST, ALP

and ALT with normal or mildly raised GGT

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    Marked GGT increase, search secondary conditions

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    Hyperkalaemia present in 30% of cases = negative

prognostic indicator

  • -

    Low urea and normal creatinine in 50% of cases due

to decreased urea formation

  • -

    Hypercholesterolaemia uncommon but if present

search for underlying pancreatitis or bile duct obstruction.

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