Feline hepatic lipidosis
Gross pathology: hepatomegaly with yellow-brown discolouration, rounded borders and increased friability.
Histopathology: microvesicular and macrovesicular vacuolar change which alters contour of hepatocytes and displaces the nucleus. Minimal inflammation.
poikilocytosis (abnormally shaped erythrocytes) in
blood smears common due to abnormal erythrocyte lipid membrane metabolism.
abnormal clotting profiles observed in up to 50% of
cats with HL. Prolongation of prothrombin time due to vitamin K deficiency most common.
Hypofibrinogenemia is common.
Clinical chemistry abnormalities
hyperbilirubinaemia with > 2x increase in AST, ALP
and ALT with normal or mildly raised GGT
Marked GGT increase, search secondary conditions
Hyperkalaemia present in 30% of cases = negative
Low urea and normal creatinine in 50% of cases due
to decreased urea formation
Hypercholesterolaemia uncommon but if present
search for underlying pancreatitis or bile duct obstruction.