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Dr Rick Last Specialist Veterinary Pathologist - page 8 / 24

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Greasy Pig Disease Key gross feature

Acute, often fatal bacterial dermatitis with a peak incidence between 5 and 35 days of age. The causative organism is Staphylococcus hyicus which produces an exotoxin “exfoliatin”,. There is direct proteolysis of swine desmoglein-1 (Dsg-1), a calcium-dependant cell to cell adhesion molecule in desmosomes, by S.hyicus exfoliative toxin. Resulting in the pustular crusting lesions.

Predisposing factors include cutaneous lacerations, poor nutrition and viral infections. Dermatitis with a brownish exudate usually develops around the eyes, pinnae, snout, chin, medial legs and spreads to the ventral thorax , abdomen and coronary bands.

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