Greasy Pig Disease Key gross feature
Acute, often fatal bacterial dermatitis with a peak incidence between 5 and 35 days of age. The causative organism is Staphylococcus hyicus which produces an exotoxin “exfoliatin”,. There is direct proteolysis of swine desmoglein-1 (Dsg-1), a calcium-dependant cell to cell adhesion molecule in desmosomes, by S.hyicus exfoliative toxin. Resulting in the pustular crusting lesions.
Predisposing factors include cutaneous lacerations, poor nutrition and viral infections. Dermatitis with a brownish exudate usually develops around the eyes, pinnae, snout, chin, medial legs and spreads to the ventral thorax , abdomen and coronary bands.