Properties of herpesviruses
Enveloped double stranded DNA viruses.
Genome consisits of long and short fragments which may be orientated in either direction, giving a total of 4 isomers.
Alphaherpesviruses - HSV-1, HSV-2, VZV
Betaherpesviruses - CMV, HHV-6, HHV-7
Gammaherpesviruses - EBV, HHV-8
Set up latent or persistent infection following primary infection
Reactivation are more likely to take place during periods of immunosuppression
Both primary infection and reactivation are likely to be more serious in immunocompromised patients.