X hits on this document

413 views

0 shares

0 downloads

0 comments

20 / 71

Management

At present, there are only a few indications of antiviral chemo­therapy, with the high cost of antiviral drugs being a main consideration. Generally, antiviral chemotherapy is indicated where the primary infection is especially severe, where there is dissemination, where sight is threatened, and herpes simplex encephalitis.

Acyclovir – this the drug of choice for most situations at present. It is available in a number of formulations:-

I.V. (HSV infection in normal and immunocompromised patients)

Oral (treatment and long term suppression of mucocutaneous herpes and prophylaxis of HSV in immunocompromised patients)

Cream (HSV infection of the skin and mucous membranes)

Ophthalmic ointment

Famciclovir and valacyclovir – oral only, more expensive than acyclovir.

Other older agents – e.g. idoxuridine, trifluorothymidine, Vidarabine (ara-A).

These agents are highly toxic and is suitable for topical use for opthalmic infection only

Document info
Document views413
Page views413
Page last viewedMon Jan 23 08:41:14 UTC 2017
Pages71
Paragraphs617
Words5071

Comments