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Neonatal Varicella

VZV can cross the placenta in the late stages of pregnancy  to infect the fetus congenitally.

Neonatal  varicella  may vary from a mild disease to  a  fatal disseminated infection.

If  rash  in mother occurs more than 1 week  before  delivery, then sufficient immunity would have been transferred to the fetus.

Zoster immunoglobulin should be given to susceptible  pregnant women who had contact with suspected cases of varicella.

Zoster immunoglobulin should also be given to  infants  whose mothers develop varicella during the last 7 days of pregnancy  or the first 14 days after delivery.

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