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Congenital Infection

Defined  as  the  isolation of CMV from the  saliva  or  urine within 3 weeks of birth.

Commonest congenital viral infection, affects 0.3 - 1% of  all live  births.  The second most common cause  of  mental  handicap after  Down's syndrome and is responsible for more cases of  congenital damage than rubella.

Transmission  to  the  fetus may occur  following  primary  or recurrent CMV infection. 40% chance of transmission to the  fetus following a primary infection.

May be transmitted to the fetus during all stages of pregnancy.

No  evidence  of teratogenecity, damage to the  fetus  results from destruction of target cells once they are formed.

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