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Prevention

No licensed vaccine is available. There is a candidate live attenuated vaccine known as the Towne strain but there are concerns about administering a live vaccine which could become latent and reactivates.

Prevention of CMV disease in transplant recipients is a very complicated subject and varies from center to center. It may include the following measures.

Screening and matching the CMV status of the donor and recipient

Use of CMV negative blood for transfusions

Administration of CMV immunoglobulin to seronegative recipients prior to transplant

Give antiviral agents such as acyclovir and ganciclovir prophylactically.

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