Burkitt’s Lymphoma (1)
Burkitt's lymphoma (BL) occurs endemically in parts of Africa (where it is the commonest childhood tumour) and Papua New Guinea. It usually occurs in children aged 3-14 years. It respond favorably to chemotherapy.
It is restricted to areas with holoendemic malaria. Therefore it appears that malaria infection is a cofactor.
Multiple copies of EBV genome and some EBV antigens can be found in BL cells and patients with BL have high titres of antibodies against various EBV antigens.