X hits on this document

382 views

0 shares

0 downloads

0 comments

58 / 71

Burkitt’s Lymphoma (2)

BL cells show a reciprocal translocation between the long arm of chromosome 8 and chromosomes 14, 2 or 22.

This translocation result in the c-myc oncogene being transferred to the Immunoglobulin gene regions. This results in the deregulation of the c-myc gene.  It is thought that this translocation is probably already present by the time of EBV infection and is not caused by EBV.

Sporadic cases of BL occur, especially in AIDS patients which may or may not be associated with EBV.

In theory BL can be controlled by the eradication of malaria (as has happened in Papua New Guinea) or vaccination against EBV.

Document info
Document views382
Page views382
Page last viewedWed Jan 18 22:56:30 UTC 2017
Pages71
Paragraphs617
Words5071

Comments