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Burkitt’s Lymphoma (2)

BL cells show a reciprocal translocation between the long arm of chromosome 8 and chromosomes 14, 2 or 22.

This translocation result in the c-myc oncogene being transferred to the Immunoglobulin gene regions. This results in the deregulation of the c-myc gene.  It is thought that this translocation is probably already present by the time of EBV infection and is not caused by EBV.

Sporadic cases of BL occur, especially in AIDS patients which may or may not be associated with EBV.

In theory BL can be controlled by the eradication of malaria (as has happened in Papua New Guinea) or vaccination against EBV.

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