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Immunocompromised Patients

After primary infection, EBV maintains a steady low grade latent infection in the body. Should the person become immunocompromised, the virus will reactivate. In a few cases, lymphoproliferative lesions and lymphoma may develop. These lesions tend to be extranodal and in unusual sites such as the GI tract or the CNS.

Transplant recipients e.g. renal - EBV is associated with the development of lymphoproliferative disease and lymphoma.

AIDS patients - EBV is associated with oral leukoplakia and with various Non-Hodgekin’s lymphoma.

Ducan X-linked lymphoproliferative syndrome - this condition occurs exclusively in males who had inherited a defective gene in the X-chromosome  . This condition accounts for half of the fatal cases of IM.

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