Acute EBV infection is usually made by the heterophil antibody test and/or detection of anti-EBV VCA IgM.
Cases of Burkitt’s lymphoma should be diagnosed by histology. The tumour can be stained with antibodies to lambda light chains which should reveal a monoclonal tumour of B-cell origin. In over 90% of cases, the cells express IgM at the cell surface.
Cases of NPC should be diagnosed by histology.
The determination of the titre of anti-EBV VCA IgA in screening for early lesions of NPC and also for monitoring treatment.
A patient with with non-specific ENT symptoms who have elevated titres of EBV IgA should be given a thorough examination.