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Epidemiology and Pathogenesis

HHV-6 and HHV-7 are ubiquitous and are found worldwide.

They are transmitted mainly through contact with saliva and through breast feeding.

HHV-6 and HHV-7 infection are acquired rapidly after the age of 4 months when the effect of maternal antibody wears off.

By the time of adulthood, 90-99% of the population had been infected by both viruses.

Like other herpesviruses, HHV-6 and HHV-7 remains latent in the body after primary infection and reactivates from time to time.

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