Human Herpes Virus 8
Belong to the gammaherpesviruses subfamily of herpesviruses
Originally isolated from cells of Kaposi’s sarcoma (KS)
Now appears to be firmly associated with Kaposi’s sarcoma as well as some lesser known malignancies such as Castleman’s disease and primary effusion lymphomas
HHV-8 DNA is found in almost 100% of cases of Kaposi’s sarcoma
Most patients with KS have antibodies against HHV-8
The seroprevalence of HHV-8 is low among the general population but is high in groups of individuals susceptible to KS, such as homosexuals.
Unlike other herpesviruses, HHV-8 does not have a ubiquitous distribution.