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PRIMARY AND SECONDARY PREVENTION OF CARDIOVASCULAR DISEASES - page 22 / 38

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HDL and Triglycerides-Class 1

Low HDL and high triglycerides tend to coincide and may occur with or without high LDL levels

Associated risk

HDL-independent risk factor, 1 mg/dl decrease causes 3-4% increase in CVD risk

LDL/HDL ratio highly predictive, 1U decrease in ratio reduces risk by 50%

Benefits of intervention

Gemfibrozil: VA-HIT-22% risk reduction in patients with HDL <40mg/dl

Niacin therapy

Recommendations

Full fasting lipid profile

Diet and exercise in primary prevention

Pharmacological therapy in secondary prevention

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