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Increased sibling risk in:

MHC, susceptibility allele

Rheumatoid arthritis8DR1 DR4

Type 1 diabetes15DR3 DR4

Alkylosing spondylitis54B-27

Mutliple sclerosis20

Ulcerative colitis12

SLE                                       20

Crohn’s disease20

Major genetic loci in a number of autoimmune diseases are the MHC genes

Class I and Class IIAntigen presentation

(RA, diabetes)

ComplementSLE

TNFIBD

Autoimmune disease - genetic factors

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