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Non MHC loci

13 mapped genes-NOD mouse

18 mapped genes in human Type 1 diabetes (genome wide scan)

IDDM-2 Allelic variation of a minisatellite tandem repeat in the regulatory region of the insulin gene <expression of insulin in the thymus of susceptible individuals

Idd-3Maps to IL-2, allelic variation in coding region of IL-2

MRL 1pr/pr: Mutation in the Fas gene leading to impaired apoptosis

The same loci have been mapped in a number of different autoimmune diseases probably reflecting key immune regulatory genes

Genetic factors

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