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1. Infection

Evidence that infection may be involved in development of autoimmunity:

Disease occurrence in clusters

Discordance in identical twins

Immune pathology associated with many infectious diseases looks like autoimmune disease

Lyme diseaseBorrelia burgdorferi

Late phase is accompanied by skin lesions like scleroderma and inflammation in the joints like arthritis

Autoimmune disease - escape from immunological tolerance

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