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How could infection work?

A.

Disruption of tolerance

Smoking can trigger Goodpasture’s syndrome

Alveolar basement membrane normally not exposed to immune system

Smoking damages alveoli, exposes collagen

Anti-collagen Ag damages lung and kidney

Anti-sperm Ab produced in some men after vasectomy

Injection of myelin basic protein (MBP) produces MS-like EAE

in mice

May be triggered by injury or infection

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