X hits on this document

178 views

0 shares

0 downloads

0 comments

9 / 52

CD4+ T cells

A number of animal models of autoimmune disease are inhibited by treatment with anti-CD4 mAbs (collagen induced arthritis [CIA], EAE, Type I diabetes in NOD mice, nephritis in MRL lupus prone mice)

CD4+ T cells isolated from autoimmune donors can adoptively transfer disease to normal recipients

Activation of Th1 cells, >TNF-, IFN-, IL-12, activation of macrophages (CIA, EAE, IBD in SCID mice, diabetes in NOD mice)

Pathogenesis

Document info
Document views178
Page views178
Page last viewedSun Jan 22 12:34:45 UTC 2017
Pages52
Paragraphs639
Words2051

Comments