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Design Considerations and Operation:

A cleanroom facility may consist of multiple rooms

with different requirements for contamination

control. Rooms in a clean facility should be

maintained at static pressures higher than

atmospheric to prevent infiltration by wind. Positive

differential pressures should be maintained

between the rooms to ensure airflows from the

cleanest space to the least clean space. The only

exception to using a positive differential pressure is

when dealing with specific hazardous materials

where governmental agencies require the room to

be at a negative pressure. Pressure differentials

must be 0.05 in WC higher in an adjacent clean area

from the less clean area. This makes airflow critical.

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