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New Diagnostics in Tuberculosis: Interferon - page 19 / 38

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Cost Effectiveness

Author year

IGRA test

Population

Diel 2006

QuantiFERON

Close

Contacts

Wrighton-

T-Spot

Close

Smith 2006

Contacts

Country Germany

Switzerland

Most Cost Effective TST then a QFT if TST+

TST then T-Spot if TST+

Germany

Diel 2007

QuantiFERON

Contacts

Canada

Oxlade 2006

QuantiFERON

Immigrants

Switzerland

Diel 2007

T-Spot

Contacts

TST then a QFT if TST+

TST then a QFT if TST+ (only if LTBI low)

TST then T-Spot if TST+ slightly less than T-Spot alone

Overall cost effectiveness studies not conclusive, but suggest TST followed by IGRA as a confirmatory test may be least costly

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