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Health Canada Advisory Statement Recommendations

z 1. IGRA may be performed in TST-positive, immunocompetent adults who are at relatively low risk of being infected with TB (including casual contacts) and of progressing to active disease if infected. Persons with a positive IGRA result may be considered for treatment of LTBI.

z 2. For close contacts or those individuals who have high or increased risk of progression to active disease if infected, a TST (or both TST and IGRA) should be used, and if either is positive the contact should be considered to have LTBI.

z 3. If both TST and IGRA testing will be used, it is recommended that blood be drawn for IGRA before or on the same day as placing the TST.

Canada Communicable Disease Report Volume 33 • ACS-10, 1 November 2007

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