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New Diagnostics in Tuberculosis: Interferon - page 31 / 38

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Areas of Uncertainty

z

performance of IGRAs in persons with impaired immune systems, including persons with HIV/AIDS, those who will be treated with TNF- antagonists, and others;

z

performance and practicality of use of IGRAs in substantial numbers of persons who undergo periodic screening;

z changes in IGRAs results during therapy for both LTBI and TB disease;

z ability of IGRAs to detect reinfection after treatment for both LTBI and TB disease;

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