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Tuberculin Skin test (TST)

z 1890 Robert Koch initially tried tuberculin as a vaccine against TB

z He made the observation that “subcutaneous inoculation of tuberculin in a tuberculosis patient lead to a rise in temperature and a local reaction at inoculation site, whereas it had no such effect on the non-tuberculous”

z 1907 Clement von Pirquet showed that a skin scratch through tuberculin fluid was enough to produce evidence of tuberculin sensitivity

z 1908 Charles Mantoux presented his study of intradermal tuberculin fluid

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